Prepare your site
Before you begin planting, you will want to rid the site of as many weeds as possible and judiciously apply Roundup to the site to kill any existing vegetation such as turf. Once everything has died back, turn in (with a spading fork or tiller) a 2- to 3-inch-deep layer of compost, manure, leaf mold, or other organic matter. This is also a good time to add amendments like lime or sulfur if you need to modify soil pH.
Turning up the soil will bring to the surface dormant seed and bits of weed rhizomes or taproots. Allow the site to green up and then apply a second spray of Roundup to eliminate the second flush of unwanted vegetation. Avoid any further tilling to prevent more dormant seed from surfacing.
Two alternatives to using herbicide are digging out the vegetation by hand or smothering it. Digging is backbreaking, but when armed with perseverance and time, it is effective. Smothering also takes time and may not be entirely effective, depending on the nature of the weeds you are trying to suppress. Heavy layers of newspaper laid on top of the soil work—an entire daily New York Times is a good thickness. It will have to be checked and added to as rain and sun cause the paper to deteriorate. Black plastic also works well and is a lot easier to put down than layers of newsprint.
It takes an entire season to prepare your site by smothering. Leave the area covered until everything has died back, till it to bring up taprooted weeds that will not be killed by one application of newspaper or plastic, and cover again. If you have Canadian thistle, burdock, dandelion, or other deep-rooted weeds, however, you’re not going to kill them unless you keep the site covered for a couple of years.